PTPRA
Screen: SilverSurfer (SilverSurfer)
Condition: TA → IL5
Analysis Method
Summary
802
Total Residues
183
Screened
3
Activating Clusters
5
Inhibitory Clusters
7
Disease Variants
1D Ergotope Profile
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Ergotope scores along the protein sequence. Negative scores = inhibitory (drug would inhibit), Positive scores = activating (drug would activate).
3D Structure Views
PyMOL renders showing ergotope coloring on the protein structure.
Disease Variants
| Position | Mutation | Type | Disease | Ergotope | Source |
|---|---|---|---|---|---|
| 57 | T57N | germline | Schizophrenia | — | PMID:30594456 |
| 129 | A129V | germline | Schizophrenia | — | PMID:30594456 |
| 223 | R223W | germline | Parkinson's Disease | — | PMID:35881618 |
| 506 | E506G | germline | Schizophrenia | — | PMID:30594456 |
| 577 | T577R | germline | Schizophrenia | — | PMID:30594456 |
| 664 | V664I | germline | Schizophrenia | — | PMID:30594456 |
| 759 | R759W | germline | Schizophrenia | — | PMID:30594456 |